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Clinical data
Trade namesPrograf, Advagraf, Protopic, others
License dataEU  EMA:  by INN
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationTopical, oral, iv
ATC codeD11AH01 ( WHO ) L04AD02 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Bioavailability24% (5–67%), less after eating food rich in fat
Protein binding≥98.8%
MetabolismHepatic CYP3A4, CYP3A5
Elimination half-life11.3 h for transplant patients (range 3.5–40.6 h)
ExcretionMostly faecal

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Drug name Tacrolimus
Tacrolimus alternativeprotopic
Active substancesprograf
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