Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen) This medication may interfere with certain laboratory tests (including digoxin or cortisol levels) possibly causing false test results. Spironolactone (aldactone) wrapping 100 mg 120 the amount of packaging.
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|Pronunciation||/ ˌ s p aɪ r ə n oʊ ˈ l æ k t oʊ n / SPY -rə-noh- LAK -tohn,  / ˌ s p ɪər -/ SPEER - |
|Trade names||Aldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others|
|Pregnancy category||AU: B3 US: C (Risk not ruled out)|
|Routes of administration||By mouth,  topical |
|Drug class||Antimineralocorticoid; Steroidal antiandrogen|
|ATC code||C03DA01 ( WHO )|
|Legal status||UK: POM (Prescription only) US: ℞-only|
|Bioavailability||60–90%   |
|Protein binding||Spironolactone: 88% (to albumin and AGP)  Canrenone: 99.2% (to albumin) |
|Metabolism||Liver, others: • Deacetylation via CES • S -Oxygenation via FOM • S -Methylation via TMT • Dethioacetylation • Hydroxylation via CYP3A4 • Lactone hydrolysis via PON3)       |
|Metabolites||7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others    (All three active) |
|Elimination half-life||Spironolactone: 1.4 hours  7α-TMS: 13.8 hours  6β-OH-7α-TMS: 15.0 hrs  Canrenone: 16.5 hours |
|Excretion||Urine, bile |
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- Aldoleo 100 mg
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- Carpiaton 100 mg
- Diulactone 25 mg
- Docspirochlor 100 mg
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|Spironolactone product name||aldactacine, aldactazide, aldactazine, aldactide, aldazida, aldazide, aldoleo, aldonar, aldospirone, aldozone, alexan, alizar, almatol, alspiron, aporasnon, cardactona, cardiatone, carpiaton, diulactone, docspirochlor, docspirono, espimax, espirone, espironolactona, expal, flumach, furorese comp, hexalacton, huma-spiroton, jenaspiron, kespirona, lacalmin, lanx, laractone, letonal, macacy, merlactone, modulactone, nefrotone, noidouble, noractone, normital, novo-spiroton, novo-spirozine, novospiroton, osiren, osyrol, pilactone, pirolacton, practazin, practon, prilactone, rakudeen, rediun-e, sali-aldopur, spilactone, spiractin, spiresis, spiretic, spirix, spiro-ct, spirobene, spirobeta, spiroctan, spiroctazide, spirogamma, spirohexal, spirola, spirolacton, spirolang, spirolon, spiron, spirono, spironol, spironolacton, spironolactona, spironolactonum, spironolakton, spironolattone, spironone, spironothiazid, spirospare, spirotone, uractone, uractonum, urusonin, velactone, verospilactone, verospiron, vivitar, xenalon, youlactone|
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